產品介紹
Quidel Polyclonal Antiserum to Human C1 Inhibitor (C1 Esterase)
A300
2.0 mL
Whole Antiserum
≤ 0.1% Sodium Azide
Baboon, Dog, Rabbit
2°C to 8°C (≤ 30 days)
For long-term storage (> 30 days), aliquot and store at ≤ –20°C. Avoid repeated freeze-thaw.
For Research Use Only. Not for use in diagnostic procedures
Highly purified human C1-inhibitor was isolated from normal serum and used to immunize goats. The C1-inhibitor polyclonal antisera was tested against normal human plasma by double immunodiffusion, one-dimensional immunoelectrophoresis, quantitative radial immunodiffusion, and quantitative rocket immunoelectrophoresis. The antiserum was determined to be monospecific for C1-inhibitor at varying concentrations.
C1-inhibitor is a multispecific protease inhibitor present in human plasma and serum. Normal human serum shows a concentration of approximately 200 μg/mL. C1-inhibitor is a glycoprotein with an approximate molecular weight of 110 kD. This protein contains many glycosylation sites, so the molecular weight varies depending on the quantity of sites that are glycosylated
Applications of the C1-inhibitor polyclonal antisera have been evaluated by various research facilities, and include Western Blot 1 and Immunoblot. 2
Schwab, J. et al. “Borrelia valaisiana Resist Complement-Mediated Killing Independently of the Recruitment of Immune Regulators and Inactivation of Complement Components.” PLoS ONE 8(1): e53659.
Yasojima, K., et al. “Complement Components, but Not Complement Inhibitors, are Upregulated in Atherosclerotic Plaques.” Arteriosclerosis, Thrombosis, and Vascular Biology (2001): 1214-1219
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